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What Is Osteoarthritis?

Osteoarthritis is a chronic (long-lasting) disease, the most common form of arthritis.14

Osteoarthritis is a degenerative or “wear-and-tear” condition 16 that occurs in all the joint tissues (cartilage, bone, muscles and ligaments) of an affected joint. Osteoarthritis commonly affects knees, hands, and hips.14

There is no cure for osteoarthritis, but there are treatment options available to help reduce pain, improve function, and in some cases, delay disease progression.14

Stages of Knee Osteoarthritis

Inside an osteoarthritis joint

  1. Normal cartilage: Provides a smooth surface, allowing bones to move easily across each other.
  2. Synovial fluid: Lubricates and provides shock absorption during activity, because it contains a high concentration of hyaluronic acid.
  3. Normal bone: Provides strength and support for the body’s tissues and organs.
  4. Eroded cartilage: If completely worn away, bones may painfully scrape against each other.
  5. Osteoarthritis synovial fluid: Degeneration from osteoarthritis leads to lower production of hyaluronic acid and poorer functional quality.
  6. Osteoarthritis bone: Contains osteophytes, also called bony spur growths.

Learn more about the causes of osteoarthritis, the symptoms, and diagnosis.

Summary of Indications for Use

DUROLANE (3 mL): Symptomatic treatment of mild to moderate knee or hip osteoarthritis. In addition, DUROLANE has been approved in the EU for the symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, shoulder, elbow, wrist, fingers, and toes.

DUROLANE SJ (1 mL): Symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, elbow, wrist, fingers, and toes.

Both DUROLANE and DUROLANE SJ are also indicated for pain following joint arthroscopy in the presence of osteoarthritis within 3 months of the procedure.

There are no known contraindications.

You should not use DUROLANE if you have infections or skin disease at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children.

Risks can include transient pain, swelling and/or stiffness at the injection site.

Full prescribing information can be found in product labeling (1 mL / 3 mL).